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Vaccination: Veterinary Vaccinations

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Total 7095 results found since Jan 2013.

Tetanus Toxoid-Pulsed Monocyte Vaccination for Augmentation of Collateral Vessel Growth Vascular Medicine
Conclusions Transplantation of ttMo into pre-immunized mice strongly promotes arteriogenesis. This therapeutic approach is feasible and highly attractive for the alleviation of morbidity associated with vascular occlusive disease.
Source: JAHA:Journal of the American Heart Association - April 14, 2014 Category: Cardiology Authors: Herold, J., Francke, A., Weinert, S., Schmeisser, A., Hebel, K., Schraven, B., Roehl, F.-W., Strasser, R. H., Braun-Dullaeus, R. C. Tags: Vascular Medicine Source Type: research

Uptake of Schistosoma mansoni extracellular vesicles by human endothelial and monocytic cell lines and impact on vascular endothelial cell gene expression.
Abstract The ability of the parasitic blood fluke Schistosoma mansoni and other parasitic helminths to manipulate host biology is well recognised, but the mechanisms that underpin these phenomena are not well understood. An emerging paradigm is that helminths transfer their biological cargo to host cells by secretion of extracellular vesicles (EVs). Herein, we show that two populations of S. mansoni secreted EVs - exosome-like vesicles (ELVs) and microvesicles (MVs) - are actively internalised in two distinct human cell lines that reflect the resident cell types encountered by the parasite in vivo: human umbilical...
Source: International Journal for Parasitology - June 25, 2020 Category: Parasitology Authors: Kifle DW, Chaiyadet S, Waardenberg AJ, Wise I, Cooper M, Becker L, Doolan DL, Laha T, Sotillo J, Pearson MS, Loukas A Tags: Int J Parasitol Source Type: research

Ib-10 * a duality of roles for perforin in cd8+ t cell- glioma interactions: contributions to cytotoxicity and altered vascular permeability
Glioblastoma multiforme (GBM) is a highly aggressive malignancy of the central nervous system that exhibits extensive vascularization and a high degree of invasiveness into the surrounding brain parenchyma. Recent evidence in both animal model systems and clinical trials have demonstrated the viability of immunotherapeutic strategies at selectively targeting tumor cells, with the generation of tumor antigen-specific CD8+ T cells strongly correlating to reductions in tumor burden. We have utilized the GL261 glioma model in immune-competent C57BL/6 mice to demonstrate the efficacy of a novel picornavirus vaccination approach...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Renner, D., Jin, F., Parney, I., Pirko, I., Pavelko, K., Johnson, A. Tags: IMMUNOBIOLOGY/INFLAMMATION (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Immunogenicity and safety of xenogeneic vascular endothelial growth factor receptor-2 DNA vaccination in mice and dogs.
This study will facilitate the evaluation of the vaccine in tumor bearing animals, ranging from rodent models to dogs with spontaneous tumors. PMID: 26871296 [PubMed - as supplied by publisher]
Source: Oncotarget - February 13, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Vaccine donation supports search dogs
DOGS belonging to the Search and Rescue Dog Association (SARDA) England have received a free health check and vaccinations thanks to support from the veterinary corporate group CVS. The charity's dogs are all owned by their handlers and have recently completed a deployment helping in the parts of the UK that were hit by flooding over the winter, including Cumbria and Yorkshire. During their March national training weekend at the Castleshaw Outdoor Centre in Oldham, Vicky Weedon, a vet at the CVS practice West Mount Vets, gave all the dogs a health check and vaccinated them. Ms Weedon has a long-standing relationship with t...
Source: Veterinary Record - March 23, 2016 Category: Veterinary Research Tags: News and Reports Source Type: research

Transcriptomics of Haemophilus (Gl ässerella) parasuis serovar 5 subjected to culture conditions partially mimetic to natural infection for the search of new vaccine antigens
Haemophilus (Gl ässerella) parasuis is the etiological agent of Glässer’s disease in pigs. Control of this disorder has been traditionally based on bacterins. The search for alternative vaccines has focused mainly...
Source: BMC Veterinary Research - November 6, 2018 Category: Veterinary Research Authors: Álvaro Álvarez-Estrada, César B. Gutiérrez-Martín, Elías F. Rodríguez-Ferri and Sonia Martínez-Martínez Tags: Research article Source Type: research

Ebolavirus: Comparison of Survivor Immunology and Animal Models in the Search for a Correlate of Protection
Ebola viruses are enveloped, single-stranded RNA viruses belonging to the Filoviridae family and can cause Ebola virus disease (EVD), a serious haemorrhagic illness with up to 90% mortality. The disease was first detected in Zaire (currently the Democratic Republic of Congo) in 1976. Since its discovery, Ebola virus has caused sporadic outbreaks in Africa and was responsible for the largest 2013–2016 EVD epidemic in West Africa, which resulted in more than 28,600 cases and over 11,300 deaths. This epidemic strengthened international scientific efforts to contain the virus and develop therapeutics and vaccines. Immunology...
Source: Frontiers in Immunology - February 19, 2021 Category: Allergy & Immunology Source Type: research

Plague vaccines: new developments in an ongoing search
Appl Microbiol Biotechnol. 2021 Jun 18. doi: 10.1007/s00253-021-11389-6. Online ahead of print.ABSTRACTAs the reality of pandemic threats challenges humanity, exemplified during the ongoing SARS-CoV-2 infections, the development of vaccines targeting these etiological agents of disease has become increasingly critical. Of paramount concern are novel and reemerging pathogens that could trigger such events, including the plague bacterium Yersinia pestis. Y. pestis is responsible for more human deaths than any other known pathogen and exists globally in endemic regions of the world, including the four corners region and North...
Source: Applied Microbiology and Biotechnology - June 18, 2021 Category: Microbiology Authors: Jason A Rosenzweig Emily K Hendrix Ashok K Chopra Source Type: research

Fight Aging! Newsletter, April 2nd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - April 1, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 28th 2018
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impact on...
Source: Fight Aging! - May 27, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 27th 2022
In conclusion, this study confirms that innate immune training can be induced in aging healthy individuals as well as critically ill sepsis patients. We found that innate immune training can be induced regardless of age and there was no substantive difference in the immune trained phenotype as a function of age. We employed β-glucan as our immune training stimulus. The ability of glucan to induce the trained phenotype suggests that it may be possible to pharmacologically induce the immune trained phenotype in aging human immunocytes. Sitting Time Correlates with Mortality Risk https://www.fightaging.org/archiv...
Source: Fight Aging! - June 26, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 16th 2023
Conclusions Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue Assessment of Somatic Mosaicism as a Biomarker of Aging The Gut Microbiome of Centenarians https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/ The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other fu...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected. This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs